The performance of maximal ratio combining (MRC) in Rayleigh channels with co-channel interference (CCI) is well-known for receive arrays which are co-located. Recent work in network MIMO, edge-excited cells and base station collaboration is increasing interest in macrodiversity systems. Hence, in this paper we consider the effect of macrodiversity on MRC performance in Rayleigh fading channels with CCI. We consider the uncoded symbol error rate (SER) as our performance measure of interest and investigate how different macrodiversity power profiles affect SER performance. This is the first analytical work in this area. We derive approximate and exact symbol error rate results for M-QAM/BPSK modulations and use the analysis to provide a simple power metric. Numerical results, verified by simulations, are used in conjunction with the analysis to gain insight into the effects of the link powers on performance. © 2013 IEEE.