© Springer Science+Business Media Dordrecht 2014. This chapter looks at the challenges of global bioethics in the years ahead. As the particular version of global bioethics favored in this volume has thrown in its lot with the human rights tradition, its fate is closely connected with the latter’s prospects. Therefore, this chapter starts with a brief review of the history of this tradition. It then looks at the relationship between human rights and bioethics in the Universal Declaration. Furthermore, it examines the key pros and cons of linking up with human rights from a global bioethics point of view. Based on these historic and systematic sketches, it finally focuses on the path ahead for global bioethics and endeavors to distinguish its main challenges.