© Springer International Publishing AG, part of Springer Nature 2018. In spite of the progress made to date in the area of Human-Computer Interaction (HCI), recent experience reports by end users as well as research work have suggested that leading desktop-based Computer-Aided Translation (CAT) tool providers fail to consider the particular needs of screen reader users when developing their software. The study presented in this paper was conducted to assess the usability of two popular online CAT tools (Matecat and Memsource) that could serve as an alternative solution to inaccessible desktop applications. Findings indicate that Matecat is significantly more usable than Memsource, although changes would be needed in the former for blind translators to be able to perform a translation job completely autonomously and efficiently. Overall, our study suggests that accessibility awareness is still low in the translation technology industry, and that further research and development is needed in to guarantee equal opportunities for all in the translation market.