Peer-Reviewed Journal Details
Mandatory Fields
Ibrahim AA;Harzmann GD;Kerrigan NJ;
2009
February
Journal of Organic Chemistry
Organocatalytic dimerization of ketoketenes.
Published
25 ()
Optional Fields
74
4
A general method for the catalytic dimerization of ketoketenes is described. Tri-n-butylphosphine was found to be the optimal organocatalyst for the racemic reaction. When lithium iodide was used as an additive, the reaction was rendered selective for dimer formation (dimer/trimer > or = 16:1). Ring-opening reactions of the ketoketene dimers as well as preliminary studies toward the development of an asymmetric variant are also reported.
1520-6904
10.1021/jo8024785
Grant Details