Bernatsky S;Velásquez García HA;Spinelli JJ;Gaffney P;Smedby KE;Ramsey-Goldman R;Wang SS;Adami HO;Albanes D;Angelucci E;Ansell SM;Asmann YW;Becker N;Benavente Y;Berndt SI;Bertrand KA;Birmann BM;Boeing H;Boffetta P;Bracci PM;Brennan P;Brooks-Wilson AR;Cerhan JR;Chanock SJ;Clavel J;Conde L;Cotenbader KH;Cox DG;Cozen W;Crouch S;De Roos AJ;de Sanjose S;Di Lollo S;Diver WR;Dogan A;Foretova L;Ghesquières H;Giles GG;Glimelius B;Habermann TM;Haioun C;Hartge P;Hjalgrim H;Holford TR;Holly EA;Jackson RD;Kaaks R;Kane E;Kelly RS;Klein RJ;Kraft P;Kricker A;Lan Q;Lawrence C;Liebow M;Lightfoot T;Link BK;Maynadie M;McKay J;Melbye M;Molina TJ;Monnereau A;Morton LM;Nieters A;North KE;Novak AJ;Offit K;Purdue MP;Rais M;Riby J;Roman E;Rothman N;Salles G;Severi G;Severson RK;Skibola CF;Slager SL;Smith A;Smith MT;Southey MC;Staines A;Teras LR;Thompson CA;Tilly H;Tinker LF;Tjonneland A;Turner J;Vajdic CM;Vermeulen RCH;Vijai J;Vineis P;Virtamo J;Wang Z;Weinstein S;Witzig TE;Zelenetz A;Zeleniuch-Jacquotte A;Zhang Y;Zheng T;Zucca M;Clarke AE;

2017

Lupus Science & Medicine

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma.

Published

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4

1

Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. These data suggest several plausible genetic links between DLBCL and SLE.

2053-8790

10.1136/lupus-2016-000187