Conference Publication Details
Mandatory Fields
Glynn, M;Nwankire, C;Kinahan, D;Ducree, J
2015 28TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2015)
CLUSTER SIZING OF CANCER CELLS BY RAIL-BASED SERIAL GAP FILTRATION IN STOPPED-FLOW, CONTINUOUS SEDIMENTATION MODE
2015
January
Published
1
1 ()
Optional Fields
SEPARATION
192
195
In addition detecting circulating tumour cells (CTCs) in blood, the presence of multi-cellular clusters has recently been identified to carry further information pertaining to patient outcome. We present a label-free method of measuring the range and load of clusters in a blood sample using a size-exclusion rail operated by centrifugal microfluidics. A negative selection strategy first enriches clusters from a whole blood sample; these clusters are then processed along the rail where they resolve to a series of collection bins according to size. Analysis of the occupancy of these bins then provides metrics on the cancer-cell load carried in the blood.
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