Peer-Reviewed Journal Details
Mandatory Fields
Becker, N;Fortuny, J;Alvaro, T;Nieters, A;Maynadie, M;Foretova, L;Staines, A;Brennan, P;Boffetta, P;Cocco, PL;de Sanjose, S
2009
August
Journal of Cancer Research and Clinical Oncology
Medical history and risk of lymphoma: results of a European case-control study (EPILYMPH)
Published
18 ()
Optional Fields
NON-HODGKINS-LYMPHOMA B-VIRUS-INFECTION HEPATITIS-C VIRUS RHEUMATOID-ARTHRITIS DIABETES-MELLITUS CANCER-RISK EPIDEMIOLOGY MALIGNANCIES PREVALENCE INTERLYMPH
135
1099
1107
Lymphomas are a heterogeneous group of immune-cell malignancies. Immunology-related conditions are among the few factors for which consistent evidence exists relating them to lymphoma risk. We used the data from the European case-control study Epilymph on 2,362 lymphoma cases and 2,458 controls to investigate associations between a medical history of infectious and non-infectious diseases with overall and subentity-specific lymphoma risk. As key results, we observed an increased odds ratio (OR) for self-reported infections with hepatitis B virus (HBV, OR = 1.91, 95% CL = 1.24-2.94) and a null result for rheumatoid arthritis. Additionally, we found an increased OR for infectious mononucleosis (OR = 1.68, 95% CL = 1.14-2.48), an inverse association to frequency of sickness in childhood (OR = 0.68, 95% CL = 0.55-0.84), and-as casual finding-an increased OR with acetaminophen intake (OR = 2.29, 95% CL = 1.49-3.51). Our results are consistent with the current knowledge about the association with mononucleosis as indicator of Epstein-Barr-virus infection, suggest serological study of the association to HBV infection and do not support the view of a positive association between rheumatoid arthritis and lymphoma risk.
NEW YORK
0171-5216
10.1007/s00432-009-0551-2
Grant Details