There is considerable interest in TiO2 for a wide range of applications; however, this chapter focuses mainly on its uses as a biomaterial, particularly for biomedical implant devices. The main characteristics required for this application have been considered. Methods for producing TiO2 and Ag doped TiO2 films are summarized. The interactions of the films containing body fluids, mainly with blood components such as proteins, are discussed. Various techniques, including surface analysis methods, have been employed to characterize the undoped and Ag doped TiO2 films. Their behaviour under normal conditions inside the body, such as physiological pH, has been investigated and results presented.