Callaghan, A;Ruskin, HJ;Walshe, R

Modelling and Simulation 2006

Analysis of the relative importance of the humoral versus the cellular response during the acute stage of HIV infection: results from multi-agent computer simulations.

2006

January

Published

1

0 ()

DYNAMICS IN-VIVO IMMUNE-SYSTEM SHAPE SPACE PATHOGENESIS MECHANISMS VIRUS MODEL TIME

271

276

Results of multi-agent simulations of the immune response to HIV during the acute stage of HIV infection are presented here. The model successfully recreates the viral dynamics associated with the acute phase of infection i.e. a rapid rise in viral load followed by a sharp decline to what is often referred to as a 'set point' as a result of the joint response of the humoral and cellular arms of the immune system. The results obtained from our simulations indicate that the relative strength of the cellular response is the key factor that determines the variation found in different individuals' response to infection with HIV.