Peer-Reviewed Journal Details
Mandatory Fields
Kennedy, OD;Brennan, O;Rackard, SM;Staines, A;O'Brien, FJ;Taylor, D;Lee, TC
2009
March
Journal Of Orthopaedic Research
Effects of Ovariectomy on Bone Turnover, Porosity, and Biomechanical Properties in Ovine Compact Bone 12 Months Postsurgery
Published
35 ()
Optional Fields
X-RAY ABSORPTIOMETRY CORTICAL BONE GLUCOCORTICOID APPLICATION MECHANICAL-PROPERTIES MINERAL DENSITY TRABECULAR BONE STRENGTH SHEEP EWE INCREASES
27
303
309
Compact bone makes up approximately 80% of the human skeleton by mass; but there are little data available on the effects of increased bone turnover on compact bone mechanical and material properties. This study addresses this question by measuring intracortical remodeling, resorption cavity number, and porosity in an ovariectomized (OVX) sheep model, and measures changes in biomechanical properties. Thirty-eight sheep were divided into two groups. Group 1 were controls (n =19), and Group 2 were ovariectomized (OVX; n =19). Fluorochrome dyes were administered intravenously to both groups at five time points over 12 months post-OVX to label sites of bone turnover. At 12 months post-OVX all animals were euthanized. Samples were harvested from the left metatarsal and were analyzed for intracortical bone turnover at five time points, the number of resorption cavities, and the level of intracortical porosity. The effects of these parameters on bone biomechanical properties were then measured. Bone turnover was increased in the OVX group at 6, 9, and 12 months (p < 0.05). Resorption was also higher in the OVX group at 12 months (p < 0.05). Furthermore, porosity was significantly increased in the OVX group at 12 months (p < 0.05). Stiffness and yield strength were reduced in the OVX group compared to controls (p = 0.05). Ultimate compressive strength and work to fracture did not differ between groups. These findings provide new insights into the mechanisms and effects of increased bone turnover on bone material and microstructural properties. (C) 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:303-309, 2009
HOBOKEN
0736-0266
10.1002/jor.20750
Grant Details