Peer-Reviewed Journal Details
Mandatory Fields
Wang S.;Vajdic C.;Linet M.;Slager S.;Voutsinas J.;Nieters A.;De Sanjose S.;Cozen W.;Alarcón G.;Martinez-Maza O.;Brown E.;Bracci P.;Lightfoot T.;Turner J.;Hjalgrim H.;Spinelli J.;Zheng T.;Morton L.;Birmann B.;Flowers C.;Paltiel O.;Becker N.;Holly E.;Kane E.;Weisenburger D.;Maynadie M.;Cocco P.;Foretova L.;Staines A.;Davis S.;Severson R.;Cerhan J.;Breen E.;Lan Q.;Brooks-Wilson A.;De Roos A.;Smith M.;Roman E.;Boffetta P.;Kricker A.;Zhang Y.;Skibola C.;Chanock S.;Rothman N.;Benavente Y.;Hartge P.;Smedby K.
American Journal of Epidemiology
Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci
27 ()
Optional Fields
autoimmune conditions environment genetics human leukocyte antigen interaction lymphoma, non-Hodgkin tumor necrosis factor
© The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).
Grant Details