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Cerhan J.;Berndt S.;Vijai J.;Ghesquières H.;McKay J.;Wang S.;Wang Z.;Yeager M.;Conde L.;De Bakker P.;Nieters A.;Cox D.;Burdett L.;Monnereau A.;Flowers C.;De Roos A.;Brooks-Wilson A.;Lan Q.;Severi G.;Melbye M.;Gu J.;Jackson R.;Kane E.;Teras L.;Purdue M.;Vajdic C.;Spinelli J.;Giles G.;Albanes D.;Kelly R.;Zucca M.;Bertrand K.;Zeleniuch-Jacquotte A.;Lawrence C.;Hutchinson A.;Zhi D.;Habermann T.;Link B.;Novak A.;Dogan A.;Asmann Y.;Liebow M.;Thompson C.;Ansell S.;Witzig T.;Weiner G.;Veron A.;Zelenika D.;Tilly H.;Haioun C.;Molina T.;Hjalgrim H.;Glimelius B.;Adami H.;Bracci P.;Riby J.;Smith M.;Holly E.;Cozen W.;Hartge P.;Morton L.;Severson R.;Tinker L.;North K.;Becker N.;Benavente Y.;Boffetta P.;Brennan P.;Foretova L.;Maynadie M.;Staines A.;Lightfoot T.;Crouch S.;Smith A.;Roman E.;Diver W.;Offit K.;Zelenetz A.;Klein R.
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
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© 2014 Nature America, Inc. All rights reserved. Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10 '13 and 3.63 × 10 '11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
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