© 2013 Future Science Ltd. All rights reserved. The field of antibody-based sensor development is progressing rapidly due to advances in the different areas of research involved. These include biological aspects, such as biomarker identification and antibody production to surface chemistry, antibody immobilization and epitope recognition, the engineering and miniaturization of countless transduction platforms, and enhanced detection strategies. Such developments will be key for the ultimate aim of antibody-based sensor research in producing small, cheap, disposable, rapid, sensitive and specific POC biosensors.