© 2015 Optical Society of America. Successful use of a single-section quantum well (QW) passively mode-locked laser (MLL) as a comb source for optical interconnects is demonstrated for the first time. Sixteen comb lines spaced by 37.6 GHz are modulated using 25 Gb/s compatible single sideband orthogonal frequency division multiplexed (SSB-OFDM) signals and transmitted over 50 km of standard single-mode fiber with bit error ratio below the 7% forward error correction limit. The system performance, analyzed on the basis of the relative intensity noise of the device, reveal the suitability of single-section QW MLLs as inexpensive comb sources for inter- and intra-data center communication scenarios.