Vijai J.;Wang Z.;Berndt S.;Skibola C.;Slager S.;De Sanjose S.;Melbye M.;Glimelius B.;Bracci P.;Conde L.;Birmann B.;Wang S.;Brooks-Wilson A.;Lan Q.;De Bakker P.;Vermeulen R.;Portlock C.;Ansell S.;Link B.;Riby J.;North K.;Gu J.;Hjalgrim H.;Cozen W.;Becker N.;Teras L.;Spinelli J.;Turner J.;Zhang Y.;Purdue M.;Giles G.;Kelly R.;Zeleniuch-Jacquotte A.;Ennas M.;Monnereau A.;Bertrand K.;Albanes D.;Lightfoot T.;Yeager M.;Chung C.;Burdett L.;Hutchinson A.;Lawrence C.;Montalvan R.;Liang L.;Huang J.;Ma B.;Villano D.;Maria A.;Corines M.;Thomas T.;Novak A.;Dogan A.;Liebow M.;Thompson C.;Witzig T.;Habermann T.;Weiner G.;Smith M.;Holly E.;Jackson R.;Tinker L.;Ye Y.;Adami H.;Smedby K.;De Roos A.;Hartge P.;Morton L.;Severson R.;Benavente Y.;Boffetta P.;Brennan P.;Foretova L.;Maynadie M.;McKay J.;Staines A.;DIver W.

2015

January

Nature Communications

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Published

28 ()

6

© 2015 Macmillan Publishers Limited. All rights reserved. Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10 '15) and HLA-B (rs2922994, P=2.43 × 10 '9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

2041-1723

10.1038/ncomms6751