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Andrew Kellett

Dr

Contact Details


X117

T: Ext. 5461
E: Andrew.Kellett@dcu.ie
Researcher Photo

Biography

Andrew Kellett is Associate Professor of Inorganic and Medicinal Chemistry in the School of Chemical Sciences at Dublin City University, Ireland. His group are based at the National Institute for Cellular Biotechnology (NICB) and Nano-Bioanalytical Research Facility (NRF) and focus on artificial gene editing, metallodrug discovery, and therapeutic nucleic acids. He is coordinator of the Horizon 2020 Marie Skłodowska-Curie Innovative Training Network (ITN) ClickGene, the Science Foundation Ireland (SFI) Career Development Award Polynuclear Platinum(II) Biomaterials (PPtBio) for Antisense Therapeutic Application and Detection of Human Genetic Disease, and his lab is also supported by the Irish Research Council and the Science Foundation Ireland funded Synthesis and Solid-State Pharmaceutical Centre. He is a graduate of Maynooth University (B.Sc.) andTechnological University Dublin (PhD) and was then appointed as A.F. Graves Postdoctoral Fellow at the Focas Research Institute until 2011 and thereafter joined the School of Chemical Sciences at Dublin City University.

Group website: http://www.andrewkellettgroup.com

Research Interests


  • Design of inorganic materials as molecular scissors for DNA excision.
  • Nucleic acid binding interactions.
  • Free radical chemical biology at the DNA interface.
  • Metallo-cytotoxic drug design and mechanism.
  • Coordinator of the multimillion EU funded Marie Curie ITN research programme, ClickGene: Click Chemistry for Future Gene Therapies to Benefit Citizens, Researchers and Industry (H2020 - MSCA - ITN). www.clickgene.eu

Funding Opportunities

Irish Research Council

Link: www.research.ie

Postgraduate and Postdoctoral scholarship funding opportunities are regularly available through the IRC. Suitable candidates wishing to join this group are welcome to apply for an IRC scholarship, for more information please contact me by email.


Book Chapters

  Year Publication
2015 'DNA oxidation profiles of copper phenanthrene chemical nucleases'
Molphy Z., Slator C., Chatgilialoglu C., Kellett A. (2015) 'DNA oxidation profiles of copper phenanthrene chemical nucleases' In: Radiation-induced and oxidative DNA damages. Lausanne: Frontiers Media. [DOI] [Details]

Peer Reviewed Journals

  Year Publication
2019 'Synthesis, self-assembly, bacterial and fungal toxicity, and preliminary biodegradation studies of a series of L-phenylalanine-derived surface-active ionic liquids'
I.V. Kapitanov; A. Jordan; Y. Karpichev; M. Spulak; L. Perez; A. Kellett, K. Kümmerer; N. Gathergood (2019) 'Synthesis, self-assembly, bacterial and fungal toxicity, and preliminary biodegradation studies of a series of L-phenylalanine-derived surface-active ionic liquids'. Green Chemistry, 21 :1777-1794 [DOI] [Details]
2019 'Molecular methods for assessment of non-covalent metallodrug-DNA interactions'
Kellett A;Molphy Z;Slator C;McKee V;Farrell NP; (2019) 'Molecular methods for assessment of non-covalent metallodrug-DNA interactions'. Chemical Society Reviews, [DOI] [Details]
2018 'A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage'
Molphy, Z;Montagner, D;Bhat, SS;Slator, C;Long, C;Erxleben, A;Kellett, A (2018) 'A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage'. Nucleic Acids Research, 46 :9918-9931 [DOI] [Details]
2018 '[Cu(TPMA)(Phen)](ClO4)2: Metallodrug Nanocontainer Delivery and Membrane Lipidomics of a Neuroblastoma Cell Line Coupled with a Liposome Biomimetic Model Focusing on Fatty Acid Reactivity'
Toniolo G.;Louka M.;Menounou G.;Fantoni N.;Mitrikas G.;Efthimiadou E.;Masi A.;Bortolotti M.;Polito L.;Bolognesi A.;Kellett A.;Ferreri C.;Chatgilialoglu C. (2018) '[Cu(TPMA)(Phen)](ClO4)2: Metallodrug Nanocontainer Delivery and Membrane Lipidomics of a Neuroblastoma Cell Line Coupled with a Liposome Biomimetic Model Focusing on Fatty Acid Reactivity'. Acs Omega, 3 (11):15952-15965 [DOI] [Details]
2019 'Polypyridyl-Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease'
Zuin Fantoni N.;Molphy Z.;Slator C.;Menounou G.;Toniolo G.;Mitrikas G.;McKee V.;Chatgilialoglu C.;Kellett A. (2019) 'Polypyridyl-Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease'. Chemistry - A European Journal, [DOI] [Details]
2018 'Innovative DNA-Targeted Metallo-prodrug Strategy Combining Histone Deacetylase Inhibition with Oxidative Stress'
McGivern T.;Slator C.;Kellett A.;Marmion C. (2018) 'Innovative DNA-Targeted Metallo-prodrug Strategy Combining Histone Deacetylase Inhibition with Oxidative Stress'. Molecular Pharmaceutics, [DOI] [Details]
2019 'Efficient DNA Condensation by a C3-Symmetric Codeine Scaffold'
McStay N.;Reilly A.;Gathergood N.;Kellett A. (2019) 'Efficient DNA Condensation by a C3-Symmetric Codeine Scaffold'. ChemPlusChem, [DOI] [Details]
2019 'Exploring the DNA binding, oxidative cleavage, and cytotoxic properties of new ternary copper(II) compounds containing 4-aminoantipyrine and N,N-heterocyclic co-ligands'
de Souza, IP;Machado, BD;de Carvalho, AB;Binatti, I;Krambrock, K;Molphy, Z;Kellett, A;Pereira-Maia, EC;Silva-Caldeira, PP (2019) 'Exploring the DNA binding, oxidative cleavage, and cytotoxic properties of new ternary copper(II) compounds containing 4-aminoantipyrine and N,N-heterocyclic co-ligands'. Journal of Molecular Structure, 1178 :18-28 [DOI] [Details]
2016 'Process-Relevant Concentrations of the Leachable bDtBPP Impact Negatively on CHO Cell Production Characteristics'
Kelly, PS;McSweeney, S;Coleman, O;Carillo, S;Henry, M;Chandran, D;Kellett, A;Bones, J;Clynes, M;Meleady, P;Barron, N (2016) 'Process-Relevant Concentrations of the Leachable bDtBPP Impact Negatively on CHO Cell Production Characteristics'. Biotechnology Progress, 32 :1547-1558 [DOI] [Details]
2017 'OPIOID ARCHITECTURES AS NEW DNA BINDING MOLECULES'
McStay, N;Molphy, Z;Gathergood, N;Kellett, A (2017) 'OPIOID ARCHITECTURES AS NEW DNA BINDING MOLECULES'. Symmetry-Culture And Science, 28 :195-198 [Details]
2018 'Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination'
Slator, C;Molphy, Z;Mckee, V;Long, C;Brown, T;Kellett, A (2018) 'Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination'. Nucleic Acids Research, 46 :2733-2750 [DOI] [Details]
2018 'In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes'
Rochford G.;Molphy Z.;Browne N.;Surlis C.;Devereux M.;McCann M.;Kellett A.;Howe O.;Kavanagh K. (2018) 'In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes'. Journal of Inorganic Biochemistry, 186 :135-146 [DOI] [Details]
2017 'C-3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'
McStay, N;Molphy, Z;Coughlan, A;Cafolla, A;McKee, V;Gathergood, N;Kellett, A (2017) 'C-3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, 45 :527-540 [DOI] [Details]
2017 'Triggering autophagic cell death with a di-manganese(II) developmental therapeutic'
Slator C;Molphy Z;McKee V;Kellett A; (2017) 'Triggering autophagic cell death with a di-manganese(II) developmental therapeutic'. Redox Biology, 12 [DOI] [Details]
2017 'Opioid architectures as new DNA binding molecules'
McStay, N.; Molphy, Z.; Gathergood, N.; Kellett. A. (2017) 'Opioid architectures as new DNA binding molecules'. Symmetry, 28 (24):195-198 [DOI] [Details]
2016 'C3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'
McStay N;Molphy Z;Coughlan A;Cafolla A;McKee V;Gathergood N;Kellett A; (2016) 'C3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, [DOI] [Details]
2016 'Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics'
Kelly PS;McSweeney S;Coleman O;Carillo S;Henry M;Chandran D;Kellett A;Bones J;Clynes M;Meleady P;Barron N; (2016) 'Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics'. Biotechnology Progress, 32 (6) [DOI] [Details]
2016 'Radical-induced purine lesion formation is dependent on DNA helical topology'
Terzidis, MA;Prisecaru, A;Molphy, Z;Barron, N;Randazzo, A;Dumont, E;Krokidis, MG;Kellett, A;Chatgilialoglu, C (2016) 'Radical-induced purine lesion formation is dependent on DNA helical topology'. Free Radical Research, 50 :91-101 [DOI] [Details]
2016 'Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity'
Thornton L.;Dixit V.;Assad L.;Ribeiro T.;Queiroz D.;Kellett A.;Casey A.;Colleran J.;Pereira M.;Rochford G.;McCann M.;O'Shea D.;Dempsey R.;McClean S.;Kia A.;Walsh M.;Creaven B.;Howe O.;Devereux M. (2016) 'Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity'. Journal of Inorganic Biochemistry, 159 :120-132 [DOI] [Details]
2016 'Anti-Pseudomonas aeruginosa activity of 1,10-phenanthroline-based drugs against both planktonic- and biofilm-growing cells'
Viganor, L;Galdino, ACM;Nunes, APF;Santos, KRN;Branquinha, MH;Devereux, M;Kellett, A;McCann, M;Santos, ALS (2016) 'Anti-Pseudomonas aeruginosa activity of 1,10-phenanthroline-based drugs against both planktonic- and biofilm-growing cells'. Journal of Antimicrobial Chemotherapy, 71 :128-134 [DOI] [Details]
2016 '[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction'
Slator C., Barron N., Howe O., Kellett A. (2016) '[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction'. ACS CHEMICAL BIOLOGY, 11 :159-171 [DOI] [Details]
2015 'Protein engineering with artificial chemical nucleases'
Larragy, R;Fitzgerald, J;Prisecaru, A;Mckee, V;Leonard, P;Kellett, A (2015) 'Protein engineering with artificial chemical nucleases'. Chemical Communications, 51 :12908-12911 [DOI] [Details]
2015 'Protein engineering with artificial chemical nucleases'
Larragy R.;Fitzgerald J.;Prisecaru A.;McKee V.;Leonard P.;Kellett A. (2015) 'Protein engineering with artificial chemical nucleases'. Chemical Communications, 51 (65):12908-12911 [DOI] [Details]
2015 'Genome Engineering with Synthetic Copper Nucleases'
Fantoni N.;Lauria T.;Kellett A. (2015) 'Genome Engineering with Synthetic Copper Nucleases'. Synlett, 26 (19):2623-2626 [DOI] [Details]
2015 'DNA Oxidation Profiles of Copper Phenanthrene Chemical Nucleases'
Molphy Z., Slator C., Chatgilialoglu C., and Kellett A. (2015) 'DNA Oxidation Profiles of Copper Phenanthrene Chemical Nucleases'. FRONTIERS IN CHEMISTRY, 3 :1-9 [DOI] [Details]
2014 'Copper phenanthrene oxidative chemical nucleases'
Molphy Z.;Prisecaru A.;Slator C.;Barron N.;McCann M.;Colleran J.;Chandran D.;Gathergood N.;Kellett A. (2014) 'Copper phenanthrene oxidative chemical nucleases'. Inorganic Chemistry, 53 (10):5392-5404 [DOI] [Details]
2014 'The phosphate clamp: Sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes'
Prisecaru A.;Molphy Z.;Kipping R.;Peterson E.;Qu Y.;Kellett A.;Farrell N. (2014) 'The phosphate clamp: Sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes'. Nucleic Acids Research, 42 (22):13474-13487 [DOI] [Details]
2013 'Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles'
McCann M.;Curran R.;Ben-Shoshan M.;McKee V.;Devereux M.;Kavanagh K.;Kellett A. (2013) 'Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles'. Polyhedron, 56 :180-188 [DOI] [Details]
2013 'A new phenanthroline-oxazine ligand: Synthesis, coordination chemistry and atypical DNA binding interaction'
McCann M.;McGinley J.;Ni K.;O'Connor M.;Kavanagh K.;McKee V.;Colleran J.;Devereux M.;Gathergood N.;Barron N.;Prisecaru A.;Kellett A. (2013) 'A new phenanthroline-oxazine ligand: Synthesis, coordination chemistry and atypical DNA binding interaction'. Chemical Communications, 49 (23):2341-2343 [DOI] [Details]
2013 'Metal-based antimicrobial protease inhibitors'
Kellett A.;Prisecaru A.;Slator C.;Molphy Z.;McCann M. (2013) 'Metal-based antimicrobial protease inhibitors'. Current Medicinal Chemistry, 20 (25):3134-3151 [DOI] [Details]
2013 'Regulating bioactivity of Cu2+ Bis-1,10-phenanthroline artificial metallonucleases with sterically functionalized pendant carboxylates'
Prisecaru A.;McKee V.;Howe O.;Rochford G.;McCann M.;Colleran J.;Pour M.;Barron N.;Gathergood N.;Kellett A. (2013) 'Regulating bioactivity of Cu2+ Bis-1,10-phenanthroline artificial metallonucleases with sterically functionalized pendant carboxylates'. Journal of Medicinal Chemistry, 56 (21):8599-8615 [DOI] [Details]
2013 'A new phenanthroline-oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction'
McCann M., McGinley J., Ni K., O'Connor M., Kavanagh K., McKee V., Colleran J., Devereux M., Gathergood N., Barron N., Prisecaru A. and Kellett A. (2013) 'A new phenanthroline-oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction'. CHEMICAL COMMUNICATIONS (PRINT), 49 :2341-2343 [DOI] [Details]
2012 'Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2′-dipyridyl'
Kellett A.;Howe O.;O'Connor M.;McCann M.;Creaven B.;McClean S.;Foltyn-Arfa Kia A.;Casey A.;Devereux M. (2012) 'Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2′-dipyridyl'. Free Radical Biology and Medicine, 53 (3):564-576 [DOI] [Details]
2012 'Deciphering the antimicrobial activity of phenanthroline chelators'
McCann M.;Kellett A.;Kavanagh K.;Devereux M.;Santos A. (2012) 'Deciphering the antimicrobial activity of phenanthroline chelators'. Current Medicinal Chemistry, 19 (17):2703-2714 [Details]
2012 'DNA cleavage reactions of the dinuclear chemotherapeutic agent copper(II) bis-1,10- Phenanthroline terephthalate'
Kellett A.;McCann M.;Howe O.;O'Connor M.;Devereux M. (2012) 'DNA cleavage reactions of the dinuclear chemotherapeutic agent copper(II) bis-1,10- Phenanthroline terephthalate'. International Journal of Clinical Pharmacology and Therapeutics, 50 (1):79-81 [DOI] [Details]
2012 'Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu 2(μ-terephthalate)(1,10-phen) 4] 2+'
Prisecaru A.;Devereux M.;Barron N.;McCann M.;Colleran J.;Casey A.;McKee V.;Kellett A. (2012) 'Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu 2(μ-terephthalate)(1,10-phen) 4] 2+'. Chemical Communications, 48 (55):6906-6908 [DOI] [Details]
2012 'In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(ii) and silver(i) complexes'
McCann M.;Santos A.;Da Silva B.;Romanos M.;Pyrrho A.;Devereux M.;Kavanagh K.;Fichtner I.;Kellett A. (2012) 'In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(ii) and silver(i) complexes'. Toxicology Research, 1 (1):47-54 [DOI] [Details]
2012 'Silver(i) complexes of 9-anthracenecarboxylic acid and imidazoles: Synthesis, structure and antimicrobial activity'
McCann M.;Curran R.;Ben-Shoshan M.;McKee V.;Tahir A.;Devereux M.;Kavanagh K.;Creaven B.;Kellett A. (2012) 'Silver(i) complexes of 9-anthracenecarboxylic acid and imidazoles: Synthesis, structure and antimicrobial activity'. Dalton Transactions, 41 (21):6516-6527 [DOI] [Details]
2012 'Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines'
O'Connor M.;Kellett A.;McCann M.;Rosair G.;McNamara M.;Howe O.;Creaven B.;McClean S.;Foltyn-Arfa Kia A.;O'Shea D.;Devereux M. (2012) 'Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines'. Journal of Medicinal Chemistry, 55 (5):1957-1968 [DOI] [Details]
2012 'Antimicrobial action of chelating agents: Repercussions on the microorganism development, virulence and pathogenesis'
Santos A.;Sodré C.;Valle R.;Silva B.;Abi-Chacra E.;Silva L.;Souza-Gonçalves A.;Sangenito L.;Gonçalves D.;Souza L.;Palmeira V.;D'Avila-Levy C.;Kneipp L.;Kellett A.;McCann M.;Branquinha M. (2012) 'Antimicrobial action of chelating agents: Repercussions on the microorganism development, virulence and pathogenesis'. Current Medicinal Chemistry, 19 (17):2715-2737 [Details]
2011 'Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development'
Kellett A., OConnor M., McCann M., Howe O., Casey A., McCarron P., McNamara M., Kennedy S., May D. D., Skell P. S., OShea D., Devereux M. (2011) 'Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development'. MEDICAL CHEMISTRY COMMUNICATIONS, 2 :569-676 [DOI] [Details]
2011 'Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with self-activating metallo-nuclease and DNA binding properties'
Kellett A., OConnor M., McCann M., McNamara M., Lynch P., Rosair G., McKee V., Creaven B., Walsh M., McClean S., Foltyn A., OShea D., Howe O., Devereux M. (2011) 'Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with self-activating metallo-nuclease and DNA binding properties'. DALTON TRANSACTIONS, 40 :1024-1027 [Details]
2010 'Hexakis(prop-2-enamide)copper(II) bis(perchlorate) and hexakis(prop-2-enamide)manganese(II) bis(perchlorate)'
Kellett, A., Rosair G., Devereux M., McNamara M., McCann M. (2010) 'Hexakis(prop-2-enamide)copper(II) bis(perchlorate) and hexakis(prop-2-enamide)manganese(II) bis(perchlorate)'. ACTA CRYSTALLOGRAPHICA SECTION C, 66 :M358-M362 [Details]
2010 'Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands'
Creaven B. S., Czeglédi E., Devereux M., Enyedy É. A., Foltyn-Arfa Kia A., Karcz D., Kellett A., McClean S., Nagy N. V., Noble A., Rockenbauer A.,Szabó-Plánka T., Walsh M. (2010) 'Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands'. DALTON TRANSACTIONS, 39 :10854-10865 [Details]
2009 'Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity'
Creaven B. S., Devereux M., Karcz D., Kellett A., McCann M., Noble A., Walsh M. (2009) 'Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity'. JOURNAL OF INORGANIC BIOCHEMISTRY, 103 :1196-1203 [Details]
2007 'Synthesis, X-ray crystal structures and biomimetic and anticancer activities of novel copper(II)benzoate complexes incorporating 2-(4'-thiazolyl)benzimidazole (thiabendazole), 2-(2-pyridyl)benzimidazole and 1,10-phenanthroline as chelating nitrogen donor ligands'
Devereux M., O'Shea D., Kellett A., McCann M., Walsh M., Egan D., Deegan C., Kgdziora K., Rosair G., Mulller-Bunz H. (2007) 'Synthesis, X-ray crystal structures and biomimetic and anticancer activities of novel copper(II)benzoate complexes incorporating 2-(4'-thiazolyl)benzimidazole (thiabendazole), 2-(2-pyridyl)benzimidazole and 1,10-phenanthroline as chelating nitrogen donor ligands'. JOURNAL OF INORGANIC BIOCHEMISTRY, 101 :881-892 [Details]
2007 'Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: X-ray crystal structures of [Cu(BZA)(2)(bipy)(H2O)], [Cu(SalH)(2)(BZDH)(2)] and [Cu(CH3COO)(2)(5,6-DMBZDH)(2)] (SalH(2) =salicylic acid; BZAH = benzoic acid; BZDH = benzimidazole and 5,6-DMBZDH=5,6-dimethylbenzimidazole)'
Devereux M., O'Shea D., O'Connor M., Grehan H., Connor G., McCann M., Rosair G., Lyng F., Kellett A., Walsh M., Egan D., Thati B. (2007) 'Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: X-ray crystal structures of [Cu(BZA)(2)(bipy)(H2O)], [Cu(SalH)(2)(BZDH)(2)] and [Cu(CH3COO)(2)(5,6-DMBZDH)(2)] (SalH(2) =salicylic acid; BZAH = benzoic acid; BZDH = benzimidazole and 5,6-DMBZDH=5,6-dimethylbenzimidazole)'. POLYHEDRON, 26 :4073-4084 [Details]
2006 'Synthesis, superoxide dismutase mimetic and anticancer activities of metal complexes of 2,2-dimethylpentanedioic acid(2dmepdaH(2)) and 3,3-dimethylpentanedioic acid(3dmepdaH(2)): X-ray crystal structures of [Cu(3dmepda)(bipy)](2)center dot 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2)center dot 4EtOH (bipy=2,2 ' bipyridine)'
Devereux M., McCann M., O'Shea D., O'Connor M., Kiely E., McKee V., Naughton D., Fisher A., Kellett A., Walsh M., Egan D., Deegan C. (2006) 'Synthesis, superoxide dismutase mimetic and anticancer activities of metal complexes of 2,2-dimethylpentanedioic acid(2dmepdaH(2)) and 3,3-dimethylpentanedioic acid(3dmepdaH(2)): X-ray crystal structures of [Cu(3dmepda)(bipy)](2)center dot 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2)center dot 4EtOH (bipy=2,2 ' bipyridine)'. BIOINORGANIC CHEMISTRY AND APPLICATIONS, 80283 [Details]

Conference Publications

  Year Publication
2018 JOURNAL OF INORGANIC BIOCHEMISTRY
Rochford, G;Molphy, Z;Browne, N;Surlis, C;Devereux, M;McCann, M;Kellett, A;Howe, O;Kavanagh, K (2018) In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes JOURNAL OF INORGANIC BIOCHEMISTRY , pp.135-146 [DOI] [Details]

Conference Contributions

  Year Publication
2016 TBSI Chemistry Seminar Series,
Andrew Kellett (2016) Metallodrugs as Inducers or Inhibitors of Chemical Nuclease Activity. [Invited Oral Presentation], TBSI Chemistry Seminar Series, Trinity College Dublin , 25-FEB-16 - 25-FEB-16 [Details]
2015 Wolfson CRL Chemical Biology Seminar Series,
Kellett A. (2015) Metallodrugs as inducers or inhibitors of chemical nuclease activity. [], Wolfson CRL Chemical Biology Seminar Series, University of Oxford , 18-NOV-15 - 18-NOV-15 [Details]
2015 13th International Symposium on Applied Bioinorganic Chemistry (ISABC13),
Kellett A. (2015) Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity. [], 13th International Symposium on Applied Bioinorganic Chemistry (ISABC13), NUI Galway , 12-JUN-15 - 15-JUN-15 [Details]
2015 Invited Lecture,
Kellett A. (2015) Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity. [], Invited Lecture, NUI Galway , 05-MAR-15 - 05-MAR-15 [Details]
2014 Brazilian Meeting on Inorganic Chemistry (BMIC) XVII, Invited Talk,
Kellett A. (2014) Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity. [], Brazilian Meeting on Inorganic Chemistry (BMIC) XVII, Invited Talk, Araxá, Brazil , 10-AUG-14 - 14-AUG-14 [Details]
2014 Invited talk,
Kellett, A. (2014) Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity. [], Invited talk, Universidade Federal do Rio de Janeiro, Brazil , 08-AUG-14 - 08-AUG-14 [Details]
2014 Invited Talk,
Kellett, Andrew (2014) Copper(II) Oxidative Chemical Nucleases. [], Invited Talk, Department of Chemistry, Loughborough University, UK , 29-JAN-14 - 29-JAN-14 [Details]
2014 EUCHEM Conference on Organic Free Radicals,
Kellett, A. (2014) Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity. [], EUCHEM Conference on Organic Free Radicals, Prague , 29-JUN-14 - 04-JUL-14 [Details]
2014 COST Action CM1201: Biomimetic Radical Chemistry, WG4/WG1 Inter-Working Group Meeting,
Kellett A. (2014) NCI‐60 chemotherapeutic action of copper metallointercalators bear apoptotic hallmarks of hydroxyl radical induced death. [], COST Action CM1201: Biomimetic Radical Chemistry, WG4/WG1 Inter-Working Group Meeting, Puerto de la Cruz, Tenerife, Spain , 01-OCT-14 - 03-OCT-14 [Details]
2014 Invited talk,
Kellett, A. (2014) Deciphering the Antimicrobial Action of Copper Phenazines through Proteomic Analysis. [], Invited talk, Universidade Federal do Rio de Janeiro, Brazil , 07-AUG-14 - 07-AUG-14 [Details]
2013 COST Action CM1201: Biomimetic Radical Chemistry, 1st Working Group Meeting (WG 2: Models of DNA Damage and Consequences),
Andrew Kellett (2013) Copper Phenanthrene Oxidative Chemical Nucleases. [], COST Action CM1201: Biomimetic Radical Chemistry, 1st Working Group Meeting (WG 2: Models of DNA Damage and Consequences), Athens, Greece , 17-OCT-13 - 19-OCT-13 [Details]
2012 2012 Symposium on Inorganic Chemistry in Ireland,
Andrew Kellett (2012) Copper Metallo-Nucleases in Cancer Chemotherapy. [], 2012 Symposium on Inorganic Chemistry in Ireland, National University of Ireland, Galway , 07-DEC-12 [Details]
2011 Chemistry Lecture Seminar Series,
Andrew Kellett (2011) DNA activation by phenanthroline dicarboxylate complexes: new frontiers for metal-based drugs?. [Conference Organising Committee Member], Chemistry Lecture Seminar Series, Dublin City University , 13-APR-11 [Details]
2011 Central European Society for Anticancer Drug Research (CESAR) Annual Meeting,
Andrew Kellett, Michael Devereux, Malachy McCann, Mark OConnor, Pauraic McCarron, Alan Casey, and Orla Howe (2011) DNA activation by phenanthroline dicarboxylate complexes: new frontiers for metal-based drugs?. [Conference Organising Committee Member], Central European Society for Anticancer Drug Research (CESAR) Annual Meeting, Greifswald University Germany , 16-JUN-11 - 18-JUN-11 [Details]
2010 62nd Irish Universities Chemistry Research Colloquium,
Pauraic Mc Carron, Malachy McCann, Andrew Kellett, Michael Devereux (2010) Synthesis and Chemotherapeutic Potential of Manganese(II) 1,10-Phenanthroline/Phthalate Complexes. [], 62nd Irish Universities Chemistry Research Colloquium, Queens University Belfast , 01-JUL-10 - 02-JUL-10 [Details]
2010 2nd Symposium on Inorganic Chemistry in Ireland,
Andrew Kellett, Michael Devereux, Mary McNamara, Malachy McCann, Mark OConnor, Orla Howe, Alan Casey, Sean Kennedy, Vickie McKee, Georgina Rosair (2010) Bis-Phenanthroline Copper(II) Complexes of Aromatic and Aliphatic Dicarboxylates are Potent In Vitro Antitumour Agents with ‘Self-Activating’ Metallo-Nuclease & DNA Binding Properties. [Conference Organising Committee Member], 2nd Symposium on Inorganic Chemistry in Ireland, Queens University Belfast , 17-SEP-10 [Details]
2009 Irish Institute of Metal Based Drugs (IIMBD) Symposium,
A. Kellett, M. Devereux, M. McNamara, M. McCann, M. OConnor, D. OShea, G. Rosair, V. McKee, M. Walsh and O. Howe (2009) Anti-Tumor Potential & Mechanistic Studies of New Copper(II) Complexes. [Conference Organising Committee Chairperson], Irish Institute of Metal Based Drugs (IIMBD) Symposium, Dublin Institute of Technology , 26-NOV-09 [Details]
2009 NUI Maynooth Chemistry Seminar Series,
Andrew Kellett, Michael Devereux, Mary McNamara, Malachy McCann, Mark OConnor, Orla Howe, Alan Casey, Sean Kennedy, Vickie McKee, Georgina Rosair (2009) Anti-Tumor Potential & Mechanistic Studies of New Copper(II) Complexes. [], NUI Maynooth Chemistry Seminar Series, National University of Ireland Maynooth , 14-OCT-09 [Details]
2007 59th Irish Universities Chemistry Research Colloquium,
Michael Devereux, Denis OShea, Mark OConnor, Helen Grehan, Gavin Connor, Malachy McCann, Georgina Rosair, Fiona Lyng, Andrew Kellett, Maureen Walsh, Denise Egan and Bhumika Thati (2007) Copper(II) Superoxide Dismutase Mimetics as Potential Anticancer Drugs. [], 59th Irish Universities Chemistry Research Colloquium, Dublin City University , 13-JUN-07 - 15-JUN-07 [Details]
2006 Central European Society for Anticancer Drug Research (CESAR) Annual Meeting,
McCann M., Rowan R., Devereux D., Kellett A., Hilger R. (2006) Silver Bullets in Anticancer Chemotherapy. [Conference Organising Committee Member], Central European Society for Anticancer Drug Research (CESAR) Annual Meeting, University Hospital, Essen, Germany , 12-JUL-06 [Details]
2005 3nd Annual Science Research Day ITTD,
Andrew Kelett, Maureen Walsh, Michael Devereux, Helge Muller-Bunz, Vickie McKee and Georgina Rosair (2005) Synthesis, characterisation and biological activity of copper(II) carboxylates incorporating selective N-donor ligands. [Conference Organising Committee Member], 3nd Annual Science Research Day ITTD, Institute of Technology Tallaght Dublin , 31-MAR-05 [Details]
2004 8th annual science and computing research colloquium,
Andrew Kellett, Michael Devereux, Maureen Walsh, Bernie Creaven, Malachy McCann, Denis O'Shea, Helge Muller-Bunz (2004) Novel Cu(II) Benzimidazole Complexes for the treatment of Candida Albicans Related Infections. [Conference Organising Committee Member], 8th annual science and computing research colloquium, Waterford Institute of Technology , 26-MAY-04 - 28-MAY-04 [Details]
2004 56th Irish Universities Chemistry Research Colloquium,
Andrew Kellett, Michael Devereux, Malachy McCann, Denis O'Shea, Maureen Walsh, Bernie Creaven, Helge Muller-Bunz (2004) Copper(II) benzoate complexes incorporating benzimidazole ligands: Synthesis, structures and antifungal activity. [Conference Organising Committee Member], 56th Irish Universities Chemistry Research Colloquium, University of Limerick , 23-JUN-04 - 25-JUN-04 [Details]

Abstract

  Year Publication
2017 Rational design and development of metallodrug chemotypes for therapeutic exploitation.
McGivern, T;Ude, Z;Kenny, R;Kellett, A;Marmion, CJ (2017) Rational design and development of metallodrug chemotypes for therapeutic exploitation. NEW YORK: Abstract [Details]
2017 Estrogens-functionalized metal complexes: selective anticancer and antibacterial activity.
Montagner, D;Erxleben, A;Miguel, PS;Kavanagh, K;Kellett, A (2017) Estrogens-functionalized metal complexes: selective anticancer and antibacterial activity. NEW YORK: Abstract [Details]

Review Articles

  Year Publication
2019 Molecular methods for assessment of non-covalent metallodrug-DNA interactions.
Kellett, A;Molphy, Z;Slator, C;McKee, V;Farrell, NP (2019) Molecular methods for assessment of non-covalent metallodrug-DNA interactions. CAMBRIDGE: Review Articles [DOI] [Details]
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Modules Coordinated

  Term (ID)) Title Link Subject
2019 Inorganic Chemistry Laboratory CS254Inorganic Chemistry Laboratory
2019 Quantum and Inorganic Chemistry CS308Quantum and Inorganic Chemistry
2019 Inorganic & Physical Chemistry Lab CS260Inorganic & Physical Chemistry Lab
2019 Advanced Medicinal Chemistry CS414Advanced Medicinal Chemistry
2019 Medicinal Chemistry CS311Medicinal Chemistry
2019 Advanced Inorganic Chemistry CS406Advanced Inorganic Chemistry

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