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Brendan Egan

Dr

Contact Details

Senior Lecturer In Sport and Exercise Physiology

XG05

T: +353 (0) 1 700 8803
F: +353 (0) 1 700 8888
E: brendan.egan@dcu.ie
W: https://www.researchgate.net/profile/Brendan_Egan2
Researcher Photo

Biography

Brendan holds a position as Senior Lecturer in Sport and Exercise Physiology in the School of Health and Human Performance at Dublin City University. His current research investigates the molecular regulation of skeletal muscle function and adaptation across the life course, with special interest in the synergy between nutrition and exercise interventions to optimise performance in athletes and elderly. He received his BSc Sport and Exercise Science from the University of Limerick in 2003, MSc Sport and Exercise Nutrition from Loughborough University in 2004, and PhD from Dublin City University in 2008, before completing two years of post-doctoral training with Prof. Juleen Zierath’s Integrative Physiology group at the Karolinska Institute, Sweden. His doctoral studies focussed on skeletal muscle adaptation to exercise, and in particular the continuity between acute molecular responses to individual bouts of exercise and adaptations induced by exercise training, whereas his post-doctoral training utilised animal models and in vitro cell systems to investigate the transcriptional regulation of skeletal muscle development and mechanisms of insulin resistance. He joined the faculty in the School of Public Health, Physiotherapy, and Sport Science at University College Dublin in 2011, where he spent five years, and retains a position as Visiting Associate Professor. On the sporting front, he has played inter-county Gaelic football with Sligo since 2003, and consults as a performance nutritionist to elite team sport athletes.

Research Interests

Skeletal muscle metabolism and adaptation in exercise, health and disease
My research revolves around the molecular mechanisms governing adaptation in skeletal muscle, and the central role of muscle in whole body metabolism. As the largest organ in the body, skeletal muscle typically accounts for ~40% of total body mass, and is a major player in energy balance at rest by contributing ~30% of the resting metabolic rate in adults. Skeletal muscle has a critical role in glycemic control and metabolic homeostasis by virtue of being the predominant site of glucose disposal under insulin-stimulated conditions. Importantly, insulin resistance at the level of skeletal muscle is the primary defect in type 2 diabetes mellitus (T2DM), and linked to myriad of lifestyle-related chronic disease. My work examines the molecular mechanisms that underpin adaptation to exercise in health and disease, and the essential role of treatment of metabolic disease to which physical inactivity contributes. Recent contributions have described the continuity from signals activated by acute exercise towards transcriptional and translational processes responsible for adaptation to repeated exercise (i.e. training) in skeletal muscle. These signals include phosphorylation, acetylation and DNA hypomethylation events induced by exercise within contracting skeletal muscle. From a translational perspective, my interest focuses on the ability of the intensity or mode (e.g. resistance vs. endurance) of exercise to modulate these events in the context of healthy or diseased muscle (i.e. T2DM, sarcopenia), with a view optimising exercise prescription through targeted exercise interventions. In essence, using exercise as personalised medicine.

Applied sports science and nutrition
My interest in applied sports science centres on nutrition and training interventions to optimise athletic performance, and in particular in team sports with high intensity, repeated sprint demands. Current projects include investigating the effect of resisted sled sprinting and nutrition supplementation, including beetroot juice and caffeinated chewing gum, on repeated sprint performance in team sport athletes.

Peer Reviewed Journals

  Year Publication
2017 'Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation'
Evans M, Cogan KE, Egan B (2017) 'Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation'. JOURNAL OF PHYSIOLOGY (LONDON), [DOI] [Details]
2016 'Fueling Performance: Ketones Enter the Mix'
Egan B, D'Agostino DP (2016) 'Fueling Performance: Ketones Enter the Mix'. Cell Metabolism, 24 (3):373-375 [DOI] [Details]
2016 'SnapShot: Exercise Metabolism'
Egan B, Hawley JA, Zierath JR (2016) 'SnapShot: Exercise Metabolism'. Cell Metabolism, 24 (2):342-342 [DOI] [Details]
2016 'Protein intake for athletes and active adults: Current concepts and controversies'
Egan B (2016) 'Protein intake for athletes and active adults: Current concepts and controversies'. Nutrition Bulletin, 41 (3):202-213 [DOI] [Details]
2016 'Higher rate of fat oxidation during rowing compared with cycling ergometer exercise across a range of exercise intensities'
Egan B, Ashley DT, Kennedy E, O’Connor PL, O’Gorman DJ (2016) 'Higher rate of fat oxidation during rowing compared with cycling ergometer exercise across a range of exercise intensities'. Scandinavian Journal of Medicine and Science in Sports, 26 (6):630-637 [DOI] [Details]
2016 'AMPKγ3 is dispensable for skeletal muscle hypertrophy induced by functional overload'
Riedl I, Osler ME, Björnholm M, Egan B, Nader GA, Chibalin AV, Zierath JR (2016) 'AMPKγ3 is dispensable for skeletal muscle hypertrophy induced by functional overload'. American Journal of Physiology- Endochrinology and Metabolism, 310 (6):E461-E472 [DOI] [Details]
2016 'Resisted Sled Sprint Training to Improve Sprint Performance: A Systematic Review'
Petrakos G, Morin JB, Egan B (2016) 'Resisted Sled Sprint Training to Improve Sprint Performance: A Systematic Review'. Sports medicine (Auckland, N.Z.), 46 (3):381-400 [DOI] [Details]
2015 'miRNA let-7 expression is regulated by glucose and TNF-$\alpha$ by a remote upstream promoter'
Katayama M, Sjogren RJ, Egan B, Krook A (2015) 'miRNA let-7 expression is regulated by glucose and TNF-$\alpha$ by a remote upstream promoter'. Biochemical Journal, 472 (2):147-156 [DOI] [Details]
2015 'Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells'
Sjogren RJ, Egan B, Katayama M, Zierath JR, Krook A (2015) 'Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells'. Physiological Genomics, 47 (3):45-57 [DOI] [Details]
2015 'MicroRNA-208b progressively declines after spinal cord injury in humans and is inversely related to myostatin expression'
Boon H, Sjogren RJ, Massart J, Egan B, Kostovski E, Iversen PO, Hjeltnes N, Chibalin AV, Widegren U, Zierath JR (2015) 'MicroRNA-208b progressively declines after spinal cord injury in humans and is inversely related to myostatin expression'. Physiological Reports, 3 (11) [DOI] [Details]
2014 'Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic $\beta$-cell dysfunction and death in vitro'
Krause M, Keane K, Rodrigues-Krause J, Crognale D, Egan B, De Vito G, Murphy C, Newsholme P (2014) 'Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic $\beta$-cell dysfunction and death in vitro'. Clinical Science, 126 (10):739-752 [DOI] [Details]
2013 'Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7'
Jiang LQ, Franck N, Egan B, Sjogren RJ, Katayama M, Duque-Guimaraes D, Arner P, Zierath JR, Krook A (2013) 'Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7'. American Journal of Physiology- Endochrinology and Metabolism, 305 (11):E1359-E1366 [DOI] [Details]
2013 'Exercise metabolism and the molecular regulation of skeletal muscle adaptation'
Egan B, Zierath JR (2013) 'Exercise metabolism and the molecular regulation of skeletal muscle adaptation'. Cell Metabolism, 17 (2):162-184 [DOI] [Details]
2013 'Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle'
Egan B, O'Connor PL, Zierath JR, O'Gorman DJ (2013) 'Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle'. PLoS ONE, 8 (9) [DOI] [Details]
2012 'Transient increase in homocysteine but not hyperhomocysteinemia during acute exercise at different intensities in sedentary individuals'
Iglesias-Gutierrez E, Egan B, Diaz-Martinez AE, Penalvo JL, Gonzalez-Medina A, Martinez-Camblor P, O'Gorman DJ, Ubeda N (2012) 'Transient increase in homocysteine but not hyperhomocysteinemia during acute exercise at different intensities in sedentary individuals'. PLoS ONE, 7 (12) [DOI] [Details]
2012 'Acute exercise remodels promoter methylation in human skeletal muscle'
Barrès R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, O'Gorman DJ, Zierath JR (2012) 'Acute exercise remodels promoter methylation in human skeletal muscle'. Cell Metabolism, 15 (3):405-411 [DOI] [Details]
2011 '2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training'
Egan B, Dowling P, O'Connor PL, Henry M, Meleady P, Zierath JR, O'Gorman DJ (2011) '2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training'. Proteomics, 11 (8):1413-1428 [DOI] [Details]
2010 'Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle'
Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR, O'Gorman DJ (2010) 'Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle'. JOURNAL OF PHYSIOLOGY (LONDON), 588 (10):1779-1790 [DOI] [Details]
2009 'Hunting for the SNARK in metabolic disease'
Egan B, Zierath JR (2009) 'Hunting for the SNARK in metabolic disease'. American Journal of Physiology- Endochrinology and Metabolism, 296 (5):E969-E972 [DOI] [Details]

Publications letters

  Year Publication
2015 Motion to dismiss: Insufficient evidence to mount a case against protein synthesis as the dominant mechanism causing disuse muscle atrophy in the elderly.
Carson BP, Egan B (2015) Motion to dismiss: Insufficient evidence to mount a case against protein synthesis as the dominant mechanism causing disuse muscle atrophy in the elderly. Publications letters [Details]
2016 Not a question of if, but how best to employ HIIT in metabolic disease.
Cogan KE, Egan B (2016) Not a question of if, but how best to employ HIIT in metabolic disease. Publications letters [Details]

Professional Associations

  Association Function From / To
Irish Endocrine Society Member /
The Physiological Society Ordinary member /
European Association for the Study of Diabetes (EASD) Member /
European College of Sport Science (ECSS) Member /

Employment

  Employer Position From / To
University College Dublin Lecturer in Exercise Metabolism 03-JAN-11 / 31-MAY-16
Karolinska Institute Post-doctoral fellow 01-OCT-08 / 31-DEC-10

Education

  Year Institution Qualification Subject
2015 University College Dublin Postgraduate Diploma University Teaching and Learning
2004 Loughborough University MSc Sport and Exercise Nutrition
2003 University of Limerick BSc Sport and Exercise Science
2008 Dublin City University PhD Exercise physiology